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Paxil pharmacology

Paroxetine - DrugBank Paroxetine, also known by the trade names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Paroxetine - DrugBank
Get DrugBank to go. Paxil Tablet, film coated 30 mg/1 Oral Apotex Corporation 2011-01-01. Pharmacology; Indication Labeled indications include.

PRESCRIBING INFORMATION PAXIL CR Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of depression, panic, anxiety, obsessive compulsive disorders (OCD) and other related disorders. PRESCRIBING INFORMATION <i>PAXIL</i> CR
PRESCRIBING INFORMATION. PAXIL CR ® paroxetine hydrocoride Controlled-Release Tablets. Suicidality and Antidepressant Drugs. Antidepressants increased

Paroxetine - pedia This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. Paroxetine - pedia
Paroxetine; Clinical data; Trade names Paxil, Pexeva, Seroxat, Brisdelle, Rexetin AHFS/Monograph MedlinePlus a698032 License data

MA Pharmacology Review for We've made the tough descision to no longer support early versions of Internet Explorer (8 and below) and Firefox (3 and below), for secure browsing on MNT. MA <em>Pharmacology</em> Review for
Analgesics Drugs that relieve pain. There are two main types non-narcotic analgesics for mild pain, and narcotic analgesics for severe pain.

Clinical Pharmacology - RxList Analgesics generally recommended are: Tylenol, Tylenol with codeine, Vicodin, Darvon and Ultram. Clinical <i>Pharmacology</i> - RxList
Learn about clinical pharmacology for the drug Paxil Paroxetine Hydrocoride.

Paxil, Tamoxifen May Be a Risky Combo - Unfortunately these old web browsers do not support many crucial developments in online security, and therefore represent a threat to your online security, as well as the security of MNT. <strong>Paxil</strong>, Tamoxifen May Be a Risky Combo -
Paxil, Tamoxifen May Be a Risky Combo. Study Shows Increased Risk of Death for Breast Cancer Patients Taking Antidepressant Paxil and Tamoxifen

Paxil - FDA prescribing information, side Caution should be used in the elderly because paroxetine is the most sedating and anticholinergic of the selective serotonin reuptake inhibitors The elderly are prone to SSRI/SNRI-induced hyponatremia; monitor closely 65 years In children and young adults, risks must be wehed against the benefits of taking antidepressants Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy and dosage adjustments The patient’s family should communicate any abrupt changes in behavior to the healthcare provider Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy This drug is not approved for use in pediatric patients Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (18-24 years) Use caution in patients with bipolar disorder, seizure disorder, history of suicidal thought/behavior Risk of mydriasis; may trger angle closure attack in patients with angle closure glaucoma with anatomiy narrow angles without a patent iridectomy Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) Risk of complications such as feeding difficulties, irritability, and respiratory problems reported in neonates exposed to SNRIs/SSRIs late in third trimester Risk of cardiovascular defects in infants whose mothers took drug during early pregnancy Withdraw gradually Use lower starting dose in renal impairment (Cr Cl Pregnancy category: D Teratogenic effects: Epidemiologic studies have shown that infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of congenital malformations, particularly cardiovascular malformations Use late in the third trimester associated with complications in newborns and may require prolonged hospitalization, respiratory support, and tube feeding A study of nearly 28,000 women taking SSRIs confirmed 5 previously reported birth defercts associated with paroxetine, including heart defects, anencephaly, and abdominal wall defects (BMJ 2015; 351:h3190) Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use, and it displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers (PMs) CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) that in addition to being substrates for CYP2D6, are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. <u>Paxil</u> - FDA prescribing information, side
Paxil official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more.


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